PSBLAB PUBLICATIONS

Click the PMID link to go the the PubMed listing for each paper. Papers containing work funded by the US National Institutes of Health are available for free in the PubMed Central repository. For other papers or book chapters, please e-mail to request a pdf.
2014

  • Kalifa L, Gewandter JS, Staversky RJ, Sia EA, Brookes PS, O’Reilly MA. (2014) DNA Double-Strand Breaks Activate ATM Independent of Mitochondrial Dysfunction in A549 Cells. Free Radic Biol Med. In Press (doi: 10.1016/j.freeradbiomed.2014.07.011) PMID 25048973
  • Nadtochiy SM, Brookes PS, Porter GA. (2014) SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts. Am J Physiol Heart Circ Physiol. 306: H1602-9.
    PMID 24748594
  • Nadtochiy SM, Madukwe J, Hagen F, Brookes PS. (2014) Mitochondrial targeted nitro-linoleate, a tool compound for studying cardioprotection. Br. J. Pharmacol. 171: 2091-8.
    PMID 24102583
  • Brookes PS (2014) Internet publicity of data problems in the bioscience literature correlates with enhanced corrective action. PeerJ 2: e313.
    PMID 24765564

2013

  • Queliconi BB, Marazzi TB, Vaz SM, Brookes PS, Nehrke K, Augusto O, Kowaltowski AJ. (2013) Bicarbonate Modulates Oxidative and Functional Damage in Ischemia-Reperfusion. Free Radic. Biol. Med. 55: 46-53.
    PMID 23195687
  • Redman EK, Brookes PS, Karcz MK (2013). Role of p90RSK in regulating the Crabtree effect: implications for cancer. Biochem. Soc. Trans. 41: 124-6.
    PMID 23356270
  • Lagadinou ED, Sach A, Callahan K, Rossi RM, Neering SJ, Minhajuddin M, Ashton JM, Pei S, Grose V, O’Dwyer KM, Liesveld JL, Brookes PS, Becker MW, Jordan CT. (2013) BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells. Cell Stem Cell. 12: 329-41.
    PMID 23333149
  • Wojtovich AP, Urciuoli WR, Chatterjee S, Fisher AB, Nehrke K, Brookes PS. (2013) Kir6.2 is not the mitochondrial KATP channel but is required for cardioprotection by ischemic preconditioning. Am. J. Physiol. 304: H1439-45.
    PMID 23585131
  • Wojtovich AP, Nadtochiy SM, Urciuoli WR, Smith CO, Grunnet M, Nehrke K, Brookes PS. (2013) A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel. Peer J. 1: e48.
    PMID 23638385
  • Chouchani ET, Methner C, Nadtochiy SM, Logan A, Pell VR, Ding S, James AM, Cochemé HM, Reinhold J, Lilley KS, Partridge L, Fearnley IM, Robinson AJ, Hartley RC, Smith RA, Krieg T, Brookes PS, Murphy MP. (2013) Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nat Med. 19: 753-9.
    PMID 23708290
  • Gohil VM, Zhu L, Baker CD, Cracan V, Yaseen A, Jain M, Clish CB, Brookes PS, Bakovic M, Mootha VK. (2013) Meclizine inhibits mitochondrial respiration through direct targeting of cytosolic phosphoethanolamine metabolism. J Biol Chem. 288: 35387-95.
    PMID 24142790
  • Wojtovich AP, Smith CO, Haynes CM, Nehrke KW, Brookes PS. (2013) Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel. Biochim. Biophys. Acta. 1827: 598-611.
    PMID 23291191

2012

  • Walters AM, Porter GA Jr., Brookes PS. (2012) Mitochondria as a drug target in ischemic heart disease and cardiomyopathy. Circ. Res. 111: 1222-36.
    PMID 23065345
  • Klionsky DJ, Brookes PS, et al. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544.
    PMID 22966490
  • Guo S, Olm-Shipman A, Walters A, Urciuoli WR, Devito S, Nadtochiy SM, Wojtovich AP, Brookes PS. (2012) A cell-based phenotypic assay to identify cardioprotective agents. Circ Res. 110: 948-957
    PMID 22394516
  • Bernstein SH, Venkatesh S, Li M, Lee J, Lu B, Hilchey SP, Morse KM, Metcalfe HM, Skalska J, Andreeff M, Brookes PS, Suzuki CK. (2012) The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives. Blood. 119: 3321-3329
    PMID 22323447
  • Wojtovich AP, DiStefano P, Sherman T, Brookes PS, Nehrke K. (2012) Mitochondrial ATP-sensitive potassium channel activity and hypoxic preconditioning are independent of an inwardly rectifying potassium channel subunit in Caenorhabditis elegans. FEBS Lett. 586: 428-434
    PMID 22281198
  • Nadtochiy SM, Zhu Q, Urciuoli W, Rafikov R, Black SM, Brookes PS. (2012) Nitroalkenes confer acute cardioprotection via adenine nucleotide translocase 1. J Biol Chem. 287: 3573-3580
    PMID 22158628

2011

  • Nadtochiy SM, Redman E, Rahman I, Brookes PS. (2011) Lysine deacetylation in ischaemic preconditioning: the role of SIRT1. Cardiovasc Res. 89: 643-649
    PMID 20823277
  • Ding B, Gibbs PE, Brookes PS, Maines MD. (2011) The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters ?-adrenergic receptor ligand-mediated cardiac dysfunction. FASEB J. 25: 301-313
    PMID 20876213
  • Queliconi BB, Wojtovich AP, Nadtochiy SM, Kowaltowski AJ, Brookes PS. (2011) Redox regulation of the mitochondrial K(ATP) channel in cardioprotection. Biochim Biophys Acta. 1813: 1309-1315
    PMID 21094666
  • Shi X, Yan C, Nadtochiy SM, Abe J, Brookes PS, Berk BC. (2011) p90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: a pathogenic mechanism for ischemia-reperfusion injury. J Mol Cell Cardiol. 51: 272-275
    PMID 21609719
  • Nadtochiy SM, Yao H, McBurney MW, Gu W, Guarente L, Rahman I, Brookes PS. (2011) SIRT1-mediated acute cardioprotection. Am J Physiol. 301: H1506-H1512
    PMID 21856913
  • Wojtovich AP, Nadtochiy SM, Brookes PS, Nehrke K. (2011) Ischemic preconditioning: the role of mitochondria and aging. Exp Gerontol. 47: 1-7
    PMID 22100642
  • Wojtovich AP, Sherman TA, Nadtochiy SM, Urciuoli WR, Brookes PS, Nehrke K. (2011) SLO-2 is cytoprotective and contributes to mitochondrial potassium transport. PLoS One. 6: e28287
    PMID 22145034

2010

  • Roser KS, Brookes PS, Wojtovich AP, Olson LP, Shojaie J, Parton RL, Anders MW. (2010) Mitochondrial biotransformation of omega-(phenoxy)alkanoic acids, 3-(phenoxy)acrylic acids, and omega-(1-methyl-1H-imidazol-2-ylthio)alkanoic acids: a prodrug strategy for targeting cytoprotective antioxidants to mitochondria. Bioorg Med Chem. 18: 1441-1448
    PMID 20129794
  • Gohil VM, Sheth SA, Nilsson R, Wojtovich AP, Lee JH, Perocchi F, Chen W, Clish CB, Ayata C, Brookes PS, Mootha VK. (2010) Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis. Nature Biotechnol. 28: 249-255
    PMID 20160716
  • Wojtovich AP, Williams DM, Karcz MK, Lopes CM, Gray DA, Nehrke KW, Brookes PS. (2010) A novel mitochondrial K(ATP) channel assay. Circ Res. 106: 1190-1196
    PMID 20185796
  • Caito S, Rajendrasozhan S, Cook S, Chung S, Yao H, Friedman AE, Brookes PS, Rahman I. (2010) SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. FASEB J. 24: 3145-3159
    PMID 20385619
  • Chouchani ET, Hurd TR, Nadtochiy SM, Brookes PS, Fearnley IM, Lilley KS, Smith RA, Murphy MP. (2010) Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation. Biochem J. 430: 49-59
    PMID 20533907
  • Gunter TE, Gerstner B, Lester T, Wojtovich AP, Malecki J, Swarts SG, Brookes PS, Gavin CE, Gunter KK. (2010) An analysis of the effects of Mn2+ on oxidative phosphorylation in liver, brain, and heart mitochondria using state 3 oxidation rate assays. Toxicol Appl Pharmacol. 249: 65-75
    PMID 20800605
  • Wojtovich AP, Nehrke KW, Brookes PS. (2010) The mitochondrial complex II and ATP-sensitive potassium channel interaction: quantitation of the channel in heart mitochondria. Acta Biochim Pol. 57: 431-434
    PMID 21103454

2009

  • Skalska J, Brookes PS, Nadtochiy SM, Hilchey SP, Jordan CT, Guzman ML, Maggirwar SB, Briehl MM, Bernstein SH. (2009) Modulation of cell surface protein free thiols: a potential novel mechanism of action of the sesquiterpene lactone parthenolide. PLoS One. 4: e8115
    PMID 19956548
  • Nadtochiy SM, Burwell LS, Ingraham CA, Spencer CM, Friedman AE, Pinkert CA, Brookes PS (2009) In vivo cardioprotection by S-nitroso-2-mercaptopropionyl glycine. J Mol Cell Cardiol. 46: 960-968
    PMID 19339206
  • Ingraham CA, Burwell LS, Skalska J, Brookes PS, Howell RL, Sheu S-S, Pinkert CA. (2009) NDUFS4: Creation of a mouse model mimicking a complex I disorder. Mitochondrion. 9: 204-210
    PMID 19460290
  • Prime TA, Blaikie FH, Nadtochiy SM, James AM, Dahm CC, Vitturi D, Patel RP, Hiley CR, Abakumova I, Requejo R, Chouchani E, Hurd TR, Garvey J, Taylor CT, Brookes PS, Smith RAJ, Murphy MP. (2009) A mitochondria-targeted S-nitrosothiol reversibly modulates respiration, selectively nitrosates mitochondrial thiol proteins and protects against cardiac ischemia-reperfusion injury. Proc. Natl. Acad. Sci. USA. 106: 10764-10769
    PMID 19528654
  • Hoffman DL, Brookes PS. (2009) Oxygen sensitivity of mitochondrial reactive oxygen species generation depends on metabolic conditions. J. Biol. Chem. 284: 16236-16245
    PMID 19366681
  • Burwell LS, Nadtochiy SM, Brookes PS. (2009) Cardioprotection by metabolic shut-down and gradual wake-up. J. Mol. Cell. Cardiol. 46: 804-810
    PMID 19285082
  • Nadtochiy SM, Burwell LS, Ingraham CA, Pinkert CA, Brookes PS (2009) In vivo cardioprotection by S-nitroso-2-mercaptopropionyl glycine. J. Mol. Cell. Cardiol. 46: 960-968
    PMID 19339206
  • Schopfer FJ, Batthyany C, Baker PRS, Bonacci G, Cole MP, Rudolph V, Groeger AL, Rudolph TK, Nadtochiy SM, Brookes PS, Freeman BA (2009) Detection and quantification of protein adduction by electrophilic fatty acids: mitochondrial generation of fatty acid nitroalkene derivatives. Free Radic. Biol. Med. 46: 1250-1259
    PMID 19353781
  • Nadtochiy SM, Baker PR, Freeman BA, Brookes PS. (2009) Mitochondrial nitroalkene formation and mild uncoupling in ischemic preconditioning: implications for cardioprotection. Cardiovasc Res. 82: 333-340
    PMID 19050010
  • Wojtovich AP, Brookes PS. (2009) The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels. Basic Res. Cardiol. 104: 121-129
    PMID 19242645

2008

  • Nadtochiy SM, Nauduri D, Shimanskaya TV, Sagach VF, Brookes PS. (2008) Purine release: a protective signaling mechanism of the mitochondrial permeability transition pore in ischemia. Fiziol. Zh. 54: 5-14
    PMID 19227234
  • Wojtovich AP, Burwell LS, Sherman TA, Nehrke KW, Brookes PS. (2008) The C. elegans mitochondrial KATP channel: A potential target for preconditioning. Biochem. Biophys. Res. Commun. 376: 625-628
    PMID 18809388
  • Burwell LS, Brookes PS. (2008) Mitochondria as a target for the cardioprotective effects of nitric oxide in ischemia reperfusion injury. Antiox. Redox Signal. 10: 579-599
    PMID 18052718
  • Brookes PS, Hoffman DL. (2008) Aging & Cardiac Ischemia: Mitochondrial Free Radical Considerations. Chapter 14 in “Oxidative Stress in Aging: From Model Systems to Human Diseases”. (Eds. S Miwa, K Beckman, F Muller). Springer Verlag, NY.
  • Brookes PS, Wojtovich AP, Burwell LS, Hoffman DL, Nadtochiy SM. (2008) The interaction of mitochondrial membranes with reactive oxygen and nitrogen species. In “Free Radical Effects on Membranes, Vol. 61 of Current Topics in Membranes”. (Eds. S Matalon, S Simon, D Benos). Elsevier, NY.
  • Brookes PS, Parker N, Buckingham JA, Vidal-Puig A, Halestrap AP, Gunter TE, Nicholls DG, Bernardi P, Lemasters JJ, Brand MD. (2008) UCPs: Unlikely Calcium Porters. Nature Cell Biol. 10: 1235-1237
    PMID 18978830
  • Wojtovich AP, Brookes PS. (2008) The endogenous mitochondrial complex II inhibitor malonate regulates mitochondrial ATP-sensitive potassium channels: Implications for ischemic preconditioning. Biochim. Biophys. Acta. 1777: 882-889
    PMID 18433712
  • Guijarro A, Osei-Hyiaman D, Harvey-White J, Kunos G, Suzuki S, Nadtochiy S, Brookes PS, Meguid MM. (2008) Sustained weight loss after Roux-en-Y gastric bypass is characterized by down regulation of endocannabinoids and mitochondrial function. Ann. Surg. 247: 779-790
    PMID 18438115

2007

  • Guijarro A, Suzuki S, Chen C, Kirchner H, Middleton FA, Nadtochiy SM, Brookes PS, Niijima A, Inui A Meguid MM. (2007) Characterization of weight loss and regain after Roux-en-Y gastric bypass in rats. Am. J. Physiol. 293: R1474-R1489
    PMID 17626126
  • Brookes PS, Morse K, Ray DM, Tompkins AJ, Young SM, Hilchey S, Salim S, Konopleva M, Andreeff M, Phipps R, Bernstein SH. (2007) The triterpenoid CDDO and its derivatives elicit human lymphoid cell apoptosis through a novel pathway involving the unregulated mitochondrial permeability transition pore. Cancer Res. 67:1793-1802
    PMID 17308122
  • Brookes PS. (2007) Mitochondrial production of oxidants and their role in the regulation of cellular processes. Chapter 5.3 in “Handbook of Neurochemistry and Molecular Neurobiology” 3rd Edition. Vol. 5. “Brain Energy Metabolism.” (Eds. G. Gibson & G. Dienel), Kluwer, NY.
  • Shiva S, Brookes PS, Darley-Usmar VM. (2007) Methods for measuring the regulation of respiration by nitric oxide. In “Mitochondria”, Methods in Cell Biology Series (Eds. L Pon and Eric Schon), 80: 395-416. Acad. Press/Elsevier, San Diego CA.
    PMID 17445706
  • Nadtochiy SM, Burwell LS, Young SM, Brookes PS. (2007) Cardioprotection and mitochondrial S-nitrosation: effects of S-nitroso-2-mercaptopropionyl glycine (SNO-MPG) in cardiac ischemia-reperfusion injury. J. Mol. Cell. Cardiol. 42:812-825
    PMID 17350035
  • Shiva S, Sack MN, Greer JJ, Duranski M, Ringwood LA, Burwell LS, Wang X, MacArthur PH, Shoja A, Raghavachari N, Calvert JW, Brookes PS, Lefer DJ, Gladwin MT. (2007) Nitrite augments tolerance to ischemia-reperfusion injury via the modulation of mitochondrial electron transfer. J. Exp. Med. 204:2089-2102
    PMID 17682069
  • Hoffman D, Salter JD, Brookes PS. (2007) The response of mitochondrial reactive oxygen species generation to steady-state oxygen tension: implications for hypoxic cell signaling. Am. J. Physiol. 292:H101-108
    PMID 16963616

2006

  • Nadtochiy SM, Tompkins AJ, Brookes PS. (2006) Different mechanisms of mitochondrial proton leak in ischemia-reperfusion injury and preconditioning: implications for cardioprotection and pathology. Biochem. J. 395:611-618
    PMID 16436046
  • Burwell LS, Nadtochiy SM, Tompkins AJ, Young S, Brookes PS. (2006) Direct evidence for S-nitrosation of mitochondrial complex I. Biochem. J. 394:627-634
    PMID 16371007
  • Brookes PS, Freeman RA, Barone MC. (2006) A short-cut to mitochondrial signaling and pathology. Free Rad. Biol. Med. 41:41-45
    PMID 16781451

2005

  • Itoh S, Lemay S, Osawa M, Che W, Berdirian A, Tompkins A, Brookes PS, Yan C, Abe J-I. (2005) Mitochondrial Dok-4 recruits Src kinase and regulates mitochondria-derived reactive oxygen species (ROS) and subsequent NF-kB activation in endothelial cells. J. Biol. Chem. 280:26383-26396
    PMID 15855164
  • Brand MD, Pakay JL, Ocloo A, Kokoszka J, Wallace DC, Brookes PS, Cornwall EJ. (2005) The basal proton conductance of mitochondria depends on adenine nucleotide translocase content. Biochem J. 392:353-362
    PMID 16076285
  • Tompkins AJ, Burwell LS, Digerness SB, Holman WL, Brookes PS. (2005) Mitochondrial dysfunction in cardiac ischemia-reperfusion injury: ROS from complex I, without inhibition. Biochim. Biophys. Acta. 1762:223-231
    PMID 16278076

2004

  • Shiva S, Crawford JH, Ramachandran A, Ceaser EK, Hillson T, Brookes PS, Patel R, Darley-Usmar VM. (2004) Mechanisms of the interaction of nitroxyl with mitochondria. Biochem. J. 379:357-366
    PMID 14723605
  • Brookes PS, Yoon Y, Robotham JL, Anders MW, Sheu SS. (2004) Ca2+, ATP & ROS – a mitochondrial love/hate triangle. Am. J. Physiol. 287:C817-833
    PMID 15355853
  • Brookes PS. (2004) Mitochondrial H+ Leak and ROS generation: an odd couple. Free Rad. Biol. Med. 38:12-23
    PMID 15589367
  • Shiva S, Moellering D, Ramachandran A, Levonen AL, Landar A, Venkatraman A, Ceaser E, Ulasova E, Crawford JH, Brookes PS, Patel RP, Darley-Usmar VM. (2004) Redox signaling: from nitric oxide to oxidized lipids. Biochem. Soc. Symp. 71:107-120
    PMID 15777016
  • Brookes PS, Darley-Usmar VM. (2004) Role of calcium and superoxide dismutase in sensitizing mitochondria to peroxynitrite-induced permeability transition. Am. J. Physiol. 286:H39-H46
    PMID 12933349
  • Brookes PS. (2004) Mitochondrial nitric oxide synthase. Mitochondrion 3:187-204
    PMID 16120354

2003

  • Davies JE, Digerness SB, Goldberg SP, Killingsworth CR, Katholi CR, Brookes PS, Holman WL. (2003) Intra-myocyte ion homeostasis during ischemia-reperfusion injury: effects of pharmacologic preconditioning and controlled reperfusion. Ann. Thorac. Surg. 76:1252-1258
    PMID 14530020
  • Digerness SB, Brookes PS, Goldberg SP, Katholi CR, Holman WL. (2003) Modulation of mitochondrial adenosine triphosphate-sensitive potassium channels and sodium-hydrogen exchange provide additive protection from severe ischemia-reperfusion injury. J. Thorac. Cardiovasc. Surg. 125:863-871
    PMID 12698150
  • Brookes PS, Kraus DW, Shiva S, Doeller JE, Barone MC, Patel RP, Lancaster JR, Darley-Usmar VM. (2003) Control of mitochondrial respiration by NO”, effects of low oxygen & respiratory state. J. Biol. Chem. 278:31603-31609
    PMID 12788936
  • Venkatraman A, Shiva S, Davis AJ, Bailey SM, Brookes PS, Darley-Usmar VM. (2003) Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxide. Hepatology 38:141-147
    PMID 12829996
  • Barone MC, Darley-Usmar VM, Brookes PS. (2003) Reversible inhibition of cytochrome c oxidase by peroxynitrite proceeds through ascorbate-dependent generation of nitric oxide. J. Biol. Chem. 278:27520-27524
    PMID 12743113

2002

  • Brookes PS, Pinner AL, Ramachandran A, Coward L, Barnes S, Kim H, Darley-Usmar VM. (2002) High-throughput 2D blue-native electrophoresis, a tool for functional proteomics of mitochondria and cell-signaling complexes. Proteomics. 2:969-977
    PMID 12203892
  • Brookes PS, Digerness SB, Parks DA, Darley-Usmar VM. (2002) Mitochondrial function in response to cardiac ischemia-reperfusion after oral treatment with quercetin. Free Rad. Biol. Med. 32:1220-1228
    PMID 12031906
  • Lin T-K, Hughes G, Muratovska A, Blaikie FH, Brookes PS, Darley-Usmar VM, Smith RAJ, Murphy MP. (2002) Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach. J. Biol. Chem. 277:17048-17056
    PMID 11861642
  • Brookes PS, Baggot JE. (2002) Oxidation of 10-formyl-tetrahydrofolate by complex IV of rat mitochondria. Biochemistry. 41:5633-5636
    PMID 11969424
  • Brookes PS, Shiva S, Patel RP, Darley-Usmar VM. (2002) Measurement of mitochondrial respiratory thresholds and the control of respiration by nitric oxide. Meth. Enzymol. 359:305-319
    PMID 12481582
  • Brookes PS, Levonen A-L, Shiva S, Sarti P, Darley-Usmar VM. (2002) Mitochondria: Regulators of signal transduction by reactive oxygen and nitrogen species. Free Rad. Biol. Med. 33:755-764
    PMID 12208364
  • Cooper CE, Patel RP, Brookes PS, Darley-Usmar VM. (2002) Nano-transducers in redox cell signaling; modification of thiols by reactive oxygen and nitrogen species. Trends Biochem. Sci. 27:489-492
    PMID 12368076
  • Ramachandran A, Levonen A-L, Brookes PS, Ceaser E, Shiva S, Barone M-C, Darley-Usmar VM. (2002) Mitochondria, Nitric Oxide, and Cardiovascular Dysfunction. Free Rad. Biol. Med. 33:1465-1474
    PMID 12446203
  • Brookes P, Darley-Usmar VM. (2002) Hypothesis: The mitochondrial NO signaling pathway, and the transduction of nitrosative to oxidative cell signals: an alternative function for cytochrome c oxidase. Free Rad. Biol. Med. 32:370-374
    PMID 11841927

2001

  • Dai L, Brookes PS, Darley-Usmar VM, Anderson PG. (2001) Bioenergetics in cardiac hypertrophy: mitochondrial respiration as a pathological target of nitric oxide. Am. J. Physiol. 281:H2261-2269
    PMID 11709391
  • Shiva S, Brookes PS, Patel RP, Anderson PG, Darley-Usmar VM. (2001) Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase. Proc. Natl. Acad. Sci. USA 98:7212-7217
    PMID 11416204
  • Brookes PS, Zhang J, Dai L, Zhou F, Parks DA, Darley-Usmar VM, Anderson PG. (2001) Increased sensitivity of mitochondrial respiration to inhibition by nitric oxide in cardiac hypertrophy. J. Mol. Cell. Cardiol. 33:69-82
    PMID 11133224
  • Levonen A-L, Patel RP, Brookes P, Go Y-M, Jo H, Parthasarathy S, Darley-Usmar VM. (2001) Mechanisms of cell signaling by nitric oxide and peroxynitrite: implications for the modulation of cellular oxidative and nitrosative stress. Antiox. Redox Signaling. 3:215-229
    PMID 11396477

2000

  • Brookes PS, Padilla-Salinas E, Darley-Usmar K, Eiserich JP, Freeman BA, Darley-Usmar VM, Anderson PG. (2000) Concentration dependent effects of nitric oxide on mitochondrial permeability transition and cytochrome c release. J. Biol. Chem. 275:20474-20479
    PMID 10791954
  • Brookes PS, Patel RP, Levonen A-L, Shiva S, Moellering D, Anderson PG, Jo H, Darley-Usmar VM. (2000) Cytoprotective mechanisms of nitric oxide: the role of cell signaling. In “Free Radicals in Chemistry, Biology and Medicine”. (Eds. T. Yoshikawa, S. Toyokuni, Y. Yamamoto and Y. Niato.) OICA International, London, UK. ISBN 1903063043

1999

  • Brookes PS, Bolanos JP, Heales SJR. (1999) The assumption that nitric oxide inhibits mitochondrial ATP synthesis is correct. FEBS Lett. 446:261-263
    PMID 10100854

1998

  • Changani, KK, Bell JD, Brooks KJ, Fuller BJ, Taylor-Robinson SD, Davidson BR, Brookes PS, Bates TE. (1998) Depression of liver mitochondrial complex II-linked respiration following cooling: beneficial effects of using a prostacyclin analogue during hypothermia. Cryo-Letters 19:71-78
  • Brookes PS, Land JM, Clark JB, Heales SJR. (1998) Peroxynitrite and brain mitochondria: evidence for increased proton leak. J. Neurochem. 70:2195-2202
    PMID 9572308
  • Brookes PS, Buckingham JA, Tenreiro AM, Hulbert AJ, Brand MD. (1998) The proton permeability of the inner membrane of liver mitochondria from exothermic and endothermic vertebrates and from obese rats: correlations with standard metabolic rate and phospholipid fatty acid composition. Comp. Biochem. Physiol. 119B:325-334
    PMID 9629666
  • Heales SJR, Bolaños JP, Stewart VC, Brookes PS, Land JM, Clark JB. (1998) Nitric oxide, Mitochondria & Neurological disease. Biochim. Biophys. Acta 1410:215-228
    PMID 10076028

1997

  • Brookes PS, Land JM, Clark JB, Heales SJR. (1997) Stimulation of glyceraldehyde-3-phosphate dehydrogenase by oxyhemoglobin. FEBS Lett. 416:90-92
    PMID 9369240
  • Brookes PS, Hulbert AJ, Brand MD. (1997) The proton permeability of liposomes made from mitochondrial inner membrane phospholipids: no effect of fatty acid composition. Biochim. Biophys. Acta 1330:157-164
    PMID 9408168
  • Brookes PS, Rolfe DFS, Brand MD. (1997) The proton permeability of liposomes made from mitochondrial inner membrane phospholipids: comparison with intact mitochondria. J. Memb. Biol. 155:167-174
    PMID 9049110

1996

  • Brookes PS, Rolfe DFS, Brand MD. (1996) Proton leak of mitochondrial inner membrane phospholipid liposomes. In Biothermokinetics of the living cell. (Eds. HV Westerhoff et al.) pp3-10. BTK Press, Amsterdam, NL.